Quotes by Ray Peat, PhD:

“The ratio of calcium to phosphate is very important; that’s why milk and cheese are so valuable for weight loss, or for preventing weight gain. For people who aren’t very active, low fat milk and cheese are better, because the extra fat calories aren’t needed.”

“The foods highest in phosphate, relative to calcium, are cereals, legumes, meats, and fish. Many prepared foods contain added phosphate. Foods with a higher, safe ratio of calcium to phosphate are leaves, such as kale, turnip greens, and beet greens, and many fruits, milk, and cheese.”

“Free unsaturated fatty acids turn on the stress hormones, and cortisol blocks oxidation of sugar and turns it into fatty acids and triglycerides. Keeping cortisol and stress low is the main thing. Keeping a high ratio of calcium to phosphate helps to oppose the stress metabolism.”

“Recent publication are showing that excess phosphate can increase inflammation, tissue atrophy, calcification of blood vessels, cancer, dementia, and, in general, the processes of aging.”

Feasibility Study (UK Infants): This study found that a 1-2:1 intake ratio of calcium to phosphorus is essential for infants for proper bone development. It highlights the importance of this balance early in life. (https://pubmed.ncbi.nlm.nih.gov/27612307/)

Brazilian Obesity and Ca:P Ratio Study: This research highlights the negative implications of a low Ca:P ratio. It demonstrated that low calcium intake and high phosphorus intake (common in Western diets) could be linked to an increased risk of obesity. (https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-90)

Parathyroid Function Studies: Research indicates that an imbalanced serum Ca:P ratio can be used to identify conditions affecting parathyroid function, such as primary hyperparathyroidism and hypophosphatemia. (https://www.optimaldx.com/research-blog/mineral-biomarkers-calcium-phosphorus-ratio)

High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females: https://pubmed.ncbi.nlm.nih.gov/16925861/

Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females: https://pubmed.ncbi.nlm.nih.gov/17903344/

Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake: https://pubmed.ncbi.nlm.nih.gov/19781123/

Effects of dietary phosphorus and calcium-to phosphorus ratio on calcium and bone metabolism in healthy 20- to 43-year-old Finnish women: https://www.functionalps.com/blog/wp-content/uploads/2012/04/effectso.pdf

Phosphorus balance and prostate cancer: https://pubmed.ncbi.nlm.nih.gov/10522150/

High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III123: https://ajcn.nutrition.org/article/S0002-9165(23)04949-3/fulltext?etoc=

Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans: https://pubmed.ncbi.nlm.nih.gov/3753709/







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